Title of article
Solid-phase synthesis of sulfamides
Author/Authors
Esteve، نويسنده , , Cristina and Vidal، نويسنده , , Bernat، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2002
Pages
3
From page
1019
To page
1021
Abstract
A straightforward synthesis of diversely substituted sulfamides is described. The reaction of sulfamoylating agent 1 with solid-phase bound amines to give polymer bound BOC substituted sulfamides is described. Further N-alkylation is achieved under Mitsunobu conditions. Simultaneous deprotection and cleavage of the products leads to unsymmetrically substituted sulfamides.
Keywords
Combinatorial chemistry , library , reductive amination , Diversity , Mitsunobu reaction , sulfamoylation
Journal title
Tetrahedron Letters
Serial Year
2002
Journal title
Tetrahedron Letters
Record number
1649729
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