Title of article
A novel synthesis of functionalized ketones via a nickel-catalyzed coupling reaction of zinc reagents with thiolesters
Author/Authors
Shimizu، نويسنده , , Toshiaki and Seki، نويسنده , , Masahiko، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2002
Pages
4
From page
1039
To page
1042
Abstract
Treatment of thiolesters with zinc reagents in the presence of Ni(acac)2 provided a variety of functionalized ketones in good yields. This new protocol was successfully applied to the synthesis of (+)-biotin to allow for a practical installation of the carboxybutyl chain.
Keywords
nickel and compounds , zinc and compounds , ketones , thiolesters , coupling reactions
Journal title
Tetrahedron Letters
Serial Year
2002
Journal title
Tetrahedron Letters
Record number
1649741
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