Title of article
A general synthesis of dioxolenone prodrug moieties
Author/Authors
Sun، نويسنده , , Chong-Qing and Cheng، نويسنده , , Peter T.W. and Stevenson، نويسنده , , Jay and Dejneka، نويسنده , , Tamara and Brown، نويسنده , , Baerbel and Wang، نويسنده , , Tammy C. and Robl، نويسنده , , Jeffrey A. and Poss، نويسنده , , Michael A.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2002
Pages
4
From page
1161
To page
1164
Abstract
A general method for the synthesis of dioxolenone prodrug moieties from appropriately substituted β-ketoesters is described. This novel and versatile sequence allows for the synthesis of alkyl- or aryl-substituted dioxolenone alcohols 8 or bromides 9. Coupling of the bromides 9 to prepare bis-dioxolenone phosphonate prodrug esters is also presented.
Keywords
dioxolenone prodrug moieties , phosphonate prodrugs , squalene synthase inhibitors
Journal title
Tetrahedron Letters
Serial Year
2002
Journal title
Tetrahedron Letters
Record number
1649836
Link To Document