Title of article
First asymmetric synthesis of (R)-desmethylsibutramine
Author/Authors
Krishnamurthy، نويسنده , , Dhileepkumar and Han، نويسنده , , Zhengxu and Wald، نويسنده , , Stephen A. and Senanayake، نويسنده , , Chris H.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2002
Pages
3
From page
2331
To page
2333
Abstract
A catalytic enantioselective addition of iBuLi to aldimine 3 derived from methyl amine and 1-(4-chlorophenyl) cyclobutanecarboxaldehyde is used as the key step in the asymmetric synthesis of (R)-desmethylsibutramine, a single enantiomer version of a pharmacologically active metabolite of anti-obesity drug sibutramine (Meridia®).
Keywords
Chiral ligands , desmethylsibutramine , asymmetric synthesis
Journal title
Tetrahedron Letters
Serial Year
2002
Journal title
Tetrahedron Letters
Record number
1650712
Link To Document