Title of article
Integrastatins: structure and HIV-1 integrase inhibitory activities of two novel racemic tetracyclic aromatic heterocycles produced by two fungal species
Author/Authors
Singh، نويسنده , , Sheo B. and Zink، نويسنده , , Deborah L. and Quamina، نويسنده , , Donette S. and Pelaez، نويسنده , , Fernando and Teran، نويسنده , , Ana and Felock، نويسنده , , Peter and Hazuda، نويسنده , , Daria J. Hazuda، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2002
Pages
4
From page
2351
To page
2354
Abstract
Integrastatins are two novel aromatic natural products derived from fungal fermentations who possess a novel [6/6/6/6]-ring system and are racemic despite having two asymmetric centers. These compounds inhibited the strand transfer reaction of HIV-1 integrase with IC50 values of 1.1–2.5 μM.
Journal title
Tetrahedron Letters
Serial Year
2002
Journal title
Tetrahedron Letters
Record number
1650728
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