Title of article
Optimised solid phase synthesis of a cystine-linked peptide-PNA chimera
Author/Authors
Millo، نويسنده , , Enrico and Nicolai، نويسنده , , Raffaele and Scarfi’، نويسنده , , Sonia and Scapolla، نويسنده , , Carlo and Biasotti، نويسنده , , Barbara and Benatti، نويسنده , , Umberto and Damonte، نويسنده , , Gianluca، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2002
Pages
3
From page
3057
To page
3059
Abstract
A solid phase synthesis method for a cystine-linked peptide-PNA chimera starting from different modified protected cystine monomers was developed. This strategy dramatically improved the final yield and the specificity of disulphide bond formation in this kind of oligomers, which are traditionally obtained by liquid phase coupling via oxidation of the two terminal cysteines.
Keywords
PNA , SPPS , disulphide bond
Journal title
Tetrahedron Letters
Serial Year
2002
Journal title
Tetrahedron Letters
Record number
1651245
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