Title of article
Rapid assembly of 2-aminoimidazolones on solid support
Author/Authors
Yang، نويسنده , , Kexin and Lou، نويسنده , , Boliang and Saneii، نويسنده , , Hossain، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2002
Pages
4
From page
4463
To page
4466
Abstract
A straightforward solid-phase synthesis of 2-aminoimidazolone derivatives is described. The synthesis starts with immobilization of thioureas onto solid support, followed by HBTU/DIEA assisted coupling of Boc-protected amino acids. Upon removal of the Boc group, intramolecular cyclization and simultaneous cleavage are promoted by polyamine resin to give the 2-aminoimidazolone derivatives in good yields and excellent purity.
Keywords
2-aminoimidazolones , cyclative cleavage , solid-phase combinatorial synthesis
Journal title
Tetrahedron Letters
Serial Year
2002
Journal title
Tetrahedron Letters
Record number
1652238
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