Title of article
A traceless solid-phase synthesis of 2-imidazolones
Author/Authors
Cheng، نويسنده , , Jie-Fei and Kaiho، نويسنده , , Christopher and Chen، نويسنده , , Mi and Arrhenius، نويسنده , , Thomas and Nadzan، نويسنده , , Alex، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2002
Pages
3
From page
4571
To page
4573
Abstract
A traceless solid-phase synthesis of 2-imidazolones has been developed. Polymer-bound glycerol resin was reacted with bromoacetaldehyde diethyl acetal to give the cyclic acetal bromide on the solid support. Amination of the resin-bound acetal bromide followed by urea formation by reaction with isocyanates afforded the resin-bound urea acetals. The aldehyde urea intermediate, which was released from the resin upon treatment with TFA, immediately cyclized to afford the desired 2-imidazolones in good yield and purity.
Keywords
2-imidazolone , traceless linker , solid-phase organic synthesis
Journal title
Tetrahedron Letters
Serial Year
2002
Journal title
Tetrahedron Letters
Record number
1652310
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