Title of article
Friedel–Crafts reaction of indoles with N-silyl-N,O-acetal catalyzed by Cu(OTf)2 in the presence of TMSCl leading to indolyl primary amines
Author/Authors
Sakai، نويسنده , , Norio and Hamajima، نويسنده , , Toshihiro and Konakahara، نويسنده , , Takeo، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2002
Pages
3
From page
4821
To page
4823
Abstract
A catalytic amount of copper(II) trifluoromethanesulfonate (Cu(OTf)2) in the presence of trimethylchlorosilane (TMSCl) effectively promoted the aminomethylation of indoles bearing a variety of functional groups with a N-silyl-N,O-acetal in good to excellent yields.
Keywords
Friedel–Crafts reactions , N , indoles , Primary amines , O-acetals
Journal title
Tetrahedron Letters
Serial Year
2002
Journal title
Tetrahedron Letters
Record number
1652478
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