Title of article
Synthesis of an azabicycloalkane amino acid scaffold as potential rigid dipeptide mimetic
Author/Authors
Millet، نويسنده , , Régis and Domarkas، نويسنده , , Juozas and Rombaux، نويسنده , , Pauline and Rigo، نويسنده , , Beno??t and Houssin، نويسنده , , Raymond and Hénichart، نويسنده , , Jean-Pierre، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2002
Pages
2
From page
5087
To page
5088
Abstract
Short syntheses are presented of the pseudo-dipeptide (3S,6S)-6-[(benzyloxy)carbonyl]amino-5-oxo-1,2,3,5,6,7-hexahydro-3-indolizinecarboxylic acid (1a) and of its (3S,6R) diastereoisomer (1b). The key step involves adding vinylogous β-enaminoester derived from pyroglutamic acid on an acrylate derivative. The 6,5-fused bicyclic lactam obtained may be viewed as a conformationally restricted Ala-Pro mimetic.
Keywords
5-fused bicyclic lactam , Peptidomimetic , 6 , Indolizine
Journal title
Tetrahedron Letters
Serial Year
2002
Journal title
Tetrahedron Letters
Record number
1652676
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