Title of article
A convenient solution and solid-phase synthesis of Δ5-2-oxopiperazines via N-acyliminium ions cyclization
Author/Authors
Cheng، نويسنده , , Jie-Fei and Chen، نويسنده , , Mi and Arrhenius، نويسنده , , Thomas and Nadzan، نويسنده , , Alex، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2002
Pages
3
From page
6293
To page
6295
Abstract
An extremely efficient synthesis of Δ5-2-oxopiperazines in solution phase and on solid support has been established via a Ugi four-component condensation reaction (U-4CC) followed by N-acyliminium ion cyclization between the aldehyde (acetal) functionality and the newly formed amide bond. The desired Δ5-2-oxopiperazines are obtained in excellent yields and purity.
Journal title
Tetrahedron Letters
Serial Year
2002
Journal title
Tetrahedron Letters
Record number
1653469
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