Title of article
Regioselective 1,4-trifluoromethylation of α,β-enones using ‘protect-in-situ’ methodology
Author/Authors
Sevenard، نويسنده , , Dmitri V and Sosnovskikh، نويسنده , , Vyacheslav Ya and Kolomeitsev، نويسنده , , Alexander A and Kِnigsmann، نويسنده , , Martin H and Rِschenthaler، نويسنده , , Gerd-Volker، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2003
Pages
5
From page
7623
To page
7627
Abstract
In a convenient and efficient procedure, the nucleophilic 1,4-trifluoromethylation of several α,β-enones using (trifluoromethyl)trimethylsilane was achieved. The high regioselectivity of the reaction has been reached by blocking the carbonyl moiety of the electrophile with a bulky aluminum-centered Lewis acid.
Keywords
(Trifluoromethyl)trimethylsilane , nucleophilic addition , trifluoromethylation , regioselectivity
Journal title
Tetrahedron Letters
Serial Year
2003
Journal title
Tetrahedron Letters
Record number
1654938
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