Title of article
Aqueous phosphoric acid as a mild reagent for deprotection of the t-butoxycarbonyl group
Author/Authors
Li، نويسنده , , Bryan and Bemish، نويسنده , , Raymond and Buzon، نويسنده , , Richard A. and Chiu، نويسنده , , Charles K.-F. and Colgan، نويسنده , , Stephen T. and Kissel، نويسنده , , William and Le، نويسنده , , Tung and Leeman، نويسنده , , Kyle R. and Newell، نويسنده , , Lisa and Roth، نويسنده , , Joshua، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2003
Pages
3
From page
8113
To page
8115
Abstract
Aqueous phosphoric acid (85 wt%) is an efficient and mild reagent for the deprotection of N-BOC groups. Acid sensitive functionalities including benzyl and methyl esters, TBDMS ether, CBZ and isopropylidene groups are compatible with the reaction conditions. The reactions are high yielding, and the workup is convenient.
Keywords
Phosphoric acid , Boc , Deprotection
Journal title
Tetrahedron Letters
Serial Year
2003
Journal title
Tetrahedron Letters
Record number
1655277
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