Title of article
Monitoring the synthetic procedures of commercial drugs by 2H NMR spectroscopy: The case of ibuprofen and naproxen
Author/Authors
Acetti، نويسنده , , Daniela and Brenna، نويسنده , , Elisabetta and Fronza، نويسنده , , Giovanni and Fuganti، نويسنده , , Claudio، نويسنده ,
Issue Information
ماهنامه با شماره پیاپی سال 2008
Pages
5
From page
651
To page
655
Abstract
We determined the D/H isotope ratios of some ibuprofen and naproxen samples by 2H NMR spectroscopy. Some of these values were found to be useful for collecting hints on the synthetic procedures employed to prepare these drugs. Site-specific isotope ratio analysis shows great potentials in the fight against patent infringement.
Keywords
Patent infringement , Naproxen , IBUPROFEN , Isotope ratio , NMR
Journal title
Talanta
Serial Year
2008
Journal title
Talanta
Record number
1655371
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