Title of article
Mild and efficient synthesis of carbazates and dithiocarbazates via a three-component coupling using Cs2CO3 and TBAI
Author/Authors
Fox، نويسنده , , Daniel L. and Ruxer، نويسنده , , John T. and Oliver، نويسنده , , John M. and Alford، نويسنده , , Kasey L. and Salvatore، نويسنده , , Ralph Nicholas and Ledger، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2004
Pages
5
From page
401
To page
405
Abstract
Efficient methods for the synthesis of carbazates and dithiocarbazates have been developed. In the presence of cesium carbonate (Cs2CO3) and tetrabutylammonium iodide (TBAI) a hydrazine, CO2 or CS2, and an alkyl halide underwent a three-component coupling at room temperature. Various unprotected hydrazines and alkyl halides were examined and the results demonstrated this methodology was highly chemoselective. Applications toward the synthesis of azadepsipeptides and other pseudopeptides are described.
Keywords
carbazates , dithiocarbazates , cesium carbonate , azadepsipeptide , hydrazine
Journal title
Tetrahedron Letters
Serial Year
2004
Journal title
Tetrahedron Letters
Record number
1656421
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