Title of article
Asymmetric synthesis of macrolactin analogue
Author/Authors
Kobayashi، نويسنده , , Yusuke and Fukuda، نويسنده , , Akihiro and Kimachi، نويسنده , , Tetsutaro and Ju-ichi، نويسنده , , Motoharu and Takemoto، نويسنده , , Yoshiji، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2004
Pages
4
From page
677
To page
680
Abstract
Total asymmetric synthesis of macrolactin A analogue was accomplished by the convergent strategy. Rapid access to advanced intermediate 16 through isomerization of ynone to (E,E)-conjugated dienone is a key step of this synthesis. Overall, control of all of the four stereocenters was achieved by means of asymmetric and diastereoselective reactions without using any chiral natural sources.
Keywords
asymmetric synthesis , Ynone , Isomerization , (e , E)-Conjugated dienone , macrolactin A , antibiotics , Antivirus
Journal title
Tetrahedron Letters
Serial Year
2004
Journal title
Tetrahedron Letters
Record number
1656614
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