Title of article
Efficient synthesis of novel cytotoxic cis-fused α-methylene γ-lactones from 7,14-dihydroxy-ent-kaurenes by transformation under Mitsunobu reaction conditions
Author/Authors
Aoyagi، نويسنده , , Yutaka and Gui، نويسنده , , Ming-Yu and Jin، نويسنده , , Yong-Ri and Li، نويسنده , , Xu-Wen and Noguchi، نويسنده , , Takeshi and Fukaya، نويسنده , , Haruhiko and Hasuda، نويسنده , , Tomoyo and Takeya، نويسنده , , Koichi، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2004
Pages
5
From page
1421
To page
1425
Abstract
Facile transformation of 7,14-dihydroxy-ent-kaurenes such as excisanin A (8), kamebanin (9), and kamebakaurin (10), which are abundant in plants of the genus Rabdosia species (Labiatae), to ent-abietanes was accomplished under the Mitsunobu reaction conditions. The δ, ε-unsaturated cis-fused α-methylene γ-lactones (17, 18, and 25) thus prepared showed a moderate cytotoxic activity on P388 murine leukemia cells.
Keywords
natural product , semisynthesis , ent-Kaurene , Mitsunobu reaction conditions , Cytotoxic
Journal title
Tetrahedron Letters
Serial Year
2004
Journal title
Tetrahedron Letters
Record number
1657103
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