Title of article
An efficient one-pot synthesis of annulated pyridines utilising a directed ortho-metallation/transmetallation approach
Author/Authors
Davies، نويسنده , , Antony J. and Brands، نويسنده , , Karel M.J. and Cowden، نويسنده , , Cameron J. and Dolling، نويسنده , , Ulf-H. and Lieberman، نويسنده , , David R.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2004
Pages
4
From page
1721
To page
1724
Abstract
The ortho-alkylation of Boc-protected aminopyridines with α,ω-dihaloalkanes followed by in situ cyclisation, resulted in the corresponding annulated pyridine derivatives in good to excellent yields. The effect of the alkylating and chelating agents, the transmetallation additives and the directing group was examined.
Keywords
Aminopyridines , Ring annulation , Directed ortho-metallation , Transmetallation
Journal title
Tetrahedron Letters
Serial Year
2004
Journal title
Tetrahedron Letters
Record number
1657257
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