Title of article
The first one-pot Alder-ene-reductive amination sequence
Author/Authors
Kressierer، Christoph J. نويسنده , , Christoph J. and Müller، نويسنده , , Thomas J.J.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2004
Pages
4
From page
2155
To page
2158
Abstract
Alkyne allyl alcohols 1 are cycloisomerized under Pd catalysis to give (4-alkylidene tetrahydrofuran-3-yl) acetaldehydes 2 in good yields. These mild reaction conditions are fully compatible with a subsequent reductive amination with secondary amines and formic acid. Thus, the cycloisomerization-reductive amination sequence of yne allyl alcohols 1 and secondary amines 3 furnishes β-amino ethyl alkylidene tetrahydrofurans 4 in moderate to good yields in a one-pot fashion.
Keywords
Alkynes , amination , Catalysis , domino reactions , ene reactions
Journal title
Tetrahedron Letters
Serial Year
2004
Journal title
Tetrahedron Letters
Record number
1657469
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