A one-pot oxidation–imine formation–reduction route from alcohols to amines using manganese dioxide–sodium borohydride: the synthesis of naftifine

A new procedure for the one-pot conversion of alcohols into amines is described which utilises manganese dioxide in the presence of sodium borohydride; the scope of this process is outlined, as is its application to the preparation of the topical antifungal agent, naftifine.