Title of article
Synthesis of (S)-α-tocotrienol via an enzymatic desymmetrization of an achiral chroman derivative
Author/Authors
Chênevert، نويسنده , , Robert and Courchesne، نويسنده , , Gabriel، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2002
Pages
3
From page
7971
To page
7973
Abstract
The stereoselective acylation of an achiral chromandimethanol derivative by vinyl acetate in the presence of Candida antarctica lipase in organic media gave the corresponding (S)-monoester in high enantiomeric purity (ee=98%). (S)-α-Tocotrienol was synthesized in 19% overall yield over six steps from this (S)-monoester.
Keywords
?-tocotrienol , desymmetrization , Lipase , asymmetric synthesis
Journal title
Tetrahedron Letters
Serial Year
2002
Journal title
Tetrahedron Letters
Record number
1658800
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