Title of article
Enantioselective synthesis of NK-1 receptor antagonists (+)-CP-99,994 and (+)-CP-122,721
Author/Authors
Yamazaki، نويسنده , , Naoki and Atobe، نويسنده , , Masakazu and Kibayashi، نويسنده , , Chihiro، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2002
Pages
4
From page
7979
To page
7982
Abstract
An enantioselective total synthesis of NK-1 receptor antagonists, (+)-CP-99,994 and (+)-CP-122,721, is described. The key steps are diastereoselective addition of vinyllithium to a chiral benzaldehyde oxime ether and diastereoselective borane reduction of a cyclic oxime ether.
Keywords
chiral oxime ethers , NK-1 receptor antagonist , CP-122 , 994 , 721 , CP-99
Journal title
Tetrahedron Letters
Serial Year
2002
Journal title
Tetrahedron Letters
Record number
1658804
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