Title of article
Synthesis of cyclic peptides containing nor-lanthionine bridges via a triply-orthogonal protecting group strategy
Author/Authors
Mohd Mustapa، نويسنده , , M.Firouz and Harris، نويسنده , , Richard F Mould، نويسنده , , Jessica and Chubb، نويسنده , , Nathan A.L. and Schultz، نويسنده , , Darren and Driscoll، نويسنده , , Paul C. and Tabor، نويسنده , , Alethea B. Tabor، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2002
Pages
4
From page
8363
To page
8366
Abstract
We report a new approach to the on-resin synthesis of cyclic peptides containing unnatural thioether side-chain bridges. An orthogonally protected nor-lanthionine was incorporated in a linear precursor peptide via stepwise solid-phase synthesis. This was followed by double allyl deprotection, cyclisation using PyAOP and subsequent chain-extension to give an analogue of ring C of nisin.
Journal title
Tetrahedron Letters
Serial Year
2002
Journal title
Tetrahedron Letters
Record number
1659030
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