Title of article
An efficient synthesis of 4-alkenyl/alkynyl-6-methyl-2-pyrones via Pd-catalysed coupling on 4-bromo-6-methyl-2-pyrone
Author/Authors
Marrison، نويسنده , , Lester R. and Dickinson، نويسنده , , Julia M. and Ahmed، نويسنده , , Razwan and Fairlamb، نويسنده , , Ian J.S.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2002
Pages
5
From page
8853
To page
8857
Abstract
We herein report the efficient syntheses of biologically active 4-alkenyl- and 4-alkynyl-6-methyl-2-pyrones using Pd-catalysed coupling procedures. A palladium on carbon/triphenylphosphine combination is shown to be the most effective catalyst for Sonogashira cross-coupling of several terminal acetylenes with 4-bromo-6-methyl-2-pyrone in yields of up to 95%.
Keywords
PALLADIUM , Pyrones , organometallic couplings
Journal title
Tetrahedron Letters
Serial Year
2002
Journal title
Tetrahedron Letters
Record number
1659311
Link To Document