Title of article
Regioselective synthesis of 3,6-disubstituted-2-aminoimidazo[1,2-a]pyridines
Author/Authors
Jaramillo، نويسنده , , Carlos and Carretero، نويسنده , , Juan Carlos and de Diego، نويسنده , , J.Eugenio and del Prado، نويسنده , , Miriam and Hamdouchi، نويسنده , , Chafiq and Rold?n، نويسنده , , José Luis and S?nchez-Mart??nez، نويسنده , , Concha، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2002
Pages
4
From page
9051
To page
9054
Abstract
A convenient synthesis of 3,6-disubstituted-2-aminoimidazo[1,2-a]pyridines 3 is described. A halogen–metal exchange study on building block 1 showed that use of i-propyl magnesium chloride is most effective for chemoselective functionalization at position 6. Further regiospecific metalation at position 3, followed by quenching with different electrophiles, afforded target compounds.
Journal title
Tetrahedron Letters
Serial Year
2002
Journal title
Tetrahedron Letters
Record number
1659427
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