Title of article
Asymmetric synthesis and conformational analysis of the two enantiomers of the saturated analog of the potent thrombin inhibitor MOL-376
Author/Authors
Mathew، نويسنده , , Jessy and Farber، نويسنده , , Ken and Nakanishi، نويسنده , , Hiroshi and Qabar، نويسنده , , Maher، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2003
Pages
4
From page
583
To page
586
Abstract
Asymmetric synthesis of the two enantiomers of a small molecule thrombin inhibitor is described. The key step in the synthesis is the glucose-directed chiral induction in the hetero Diels–Alder cycloaddition step. Conformational analysis indicates that the S-enantiomer is a better fit for the idealized β-strand conformation.
Journal title
Tetrahedron Letters
Serial Year
2003
Journal title
Tetrahedron Letters
Record number
1660165
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