Title of article
The 2-(4-trifluoromethylphenylsulfonyl)ethoxycarbonyl (Tsc) amino-protecting group: use in the solid-phase synthesis of pyrrole-imidazole polyamides
Author/Authors
Choi، نويسنده , , Jin-Seok and Lee، نويسنده , , Younjoo and Kim، نويسنده , , Eunmyoung and Jeong، نويسنده , , Nakcheol and Yu، نويسنده , , Hosung and Han، نويسنده , , Hogyu Han، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2003
Pages
4
From page
1607
To page
1610
Abstract
The development of the 2-(4-trifluoromethylphenylsulfonyl)ethoxycarbonyl (Tsc) function, a novel base-sensitive amino-protecting group, and its application to the preparation of DNA-binding polyamides are described. Pyrrole–imidazole polyamides were synthesized by an efficient solid-phase method under conditions compatible with Fmoc chemistry using two Tsc-protected amino acids, Tsc-Py-OH 1a and Tsc-Im-OH 1b.
Keywords
DNA , Tsc group , amino protecting group , Amino acid , distamycin
Journal title
Tetrahedron Letters
Serial Year
2003
Journal title
Tetrahedron Letters
Record number
1660753
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