Title of article
A practical synthesis of 2,2-difluoro-3-amino-propanoic acid (α,α-difluoro-β-alanine)
Author/Authors
Cheguillaume، نويسنده , , Arnaud and Lacroix، نويسنده , , Simon and Marchand-Brynaert، نويسنده , , Jacqueline، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2003
Pages
3
From page
2375
To page
2377
Abstract
Reformatsky reaction of ethyl bromodifluoroacetate with N,N-(dibenzyl)-1H-benzotriazolyl-1-methylamine gave fully protected α,α-difluoro-β-alanine. Hydrogenolysis and hydrolysis furnished α,α-difluoro-β-alanine. Further transformation into N-phthalimido-α,α-difluoro-β-alanine was described.
Keywords
difluoro-?-alanine , benzotriazolyl-1-methylamine , Reformatsky reaction
Journal title
Tetrahedron Letters
Serial Year
2003
Journal title
Tetrahedron Letters
Record number
1661214
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