Title of article
Synthesis of (+)-prelactone B
Author/Authors
Chakraborty، نويسنده , , Tushar K. and Tapadar، نويسنده , , Subhasish، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2003
Pages
3
From page
2541
To page
2543
Abstract
Radical-mediated opening of a trisubstituted epoxy alcohol using cp2TiCl was followed by diastereoselective reduction of the resulting product with a centrally located methylene group, flanked on both sides by two chiral hydroxyl-bearing carbons, to build all the three chiral centers of (+)-prelactone B 1 in their desired stereochemistries leading to the total synthesis of the molecule.
Keywords
prelactone B , Sharpless kinetic resolution , 2-Methyl-1 , 3-diol , Epoxide opening
Journal title
Tetrahedron Letters
Serial Year
2003
Journal title
Tetrahedron Letters
Record number
1661322
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