Title of article
Studies toward a synthesis of C3-epimauritine D: construction of the macrocycle
Author/Authors
Kim، نويسنده , , Young-Ah and Shin، نويسنده , , Hyo-Nim and Park، نويسنده , , Myoung-Soon and Cho، نويسنده , , Hye Jung Han، نويسنده , , So-Yeop، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2003
Pages
4
From page
2557
To page
2560
Abstract
We successfully synthesized a 14-membered cyclic enamide of C3-epimauritine D from the cis-2,3-pyrrolidinediol derivative. Treatment of the pyrrolidinediol with nitrobenzonitrile in an SNAr reaction efficiently installed the desired aryl–alkyl ether linkage on the N-heterocyclic system. Macrocyclization was successfully achieved by the use of TFFH as the peptide coupling reagent in the presence of HOAt.
Keywords
cyclopeptide alkaloid , Pyrrolidinone , Macrocyclization , pfp ester , cyclic enamide , Epimer , TFFH
Journal title
Tetrahedron Letters
Serial Year
2003
Journal title
Tetrahedron Letters
Record number
1661333
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