Title of article
Stereospecific synthesis of chiral tertiary alkyl-aryl ethers via Mitsunobu reaction with complete inversion of configuration
Author/Authors
Shi، نويسنده , , Yao-Jun and Hughes، نويسنده , , David L. and McNamara، نويسنده , , James M.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2003
Pages
3
From page
3609
To page
3611
Abstract
Mitsunobu reaction of chiral tertiary alcohol (S)-2 with phenol 3 provides the desired ether (R)-1 in moderate yields at elevated temperatures (80–100°C). The SN2 displacement pathway is evident by complete inversion of the (S)-alcohol to (R)-ether.
Keywords
Mitsunobu reaction , tertiary alcohols , alkyl aryl ether , SN2 displacement , inversion
Journal title
Tetrahedron Letters
Serial Year
2003
Journal title
Tetrahedron Letters
Record number
1661950
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