A convenient preparation of dityrosine via Miyaura borylation–Suzuki coupling of iodotyrosine derivatives

Dityrosine has been prepared from 3-iodo-l-tyrosine derivatives by sequential Miyaura borylation and Suzuki coupling reactions. A tandem borylation–coupling protocol results in improved yields of the dityrosine derivatives. Suitable protecting group strategies are employed to allow for global deprotection as the final step.