Title of article
Lipase-catalyzed resolution of 1-chloro-3-[(4-morpholin-4-yl-1,2,5-thiadiazole-3-yl)oxy]propan-2-ol: Synthesis of (R)- and (S)-timolol
Author/Authors
Kamal، نويسنده , , Ahmed and Krishnaji، نويسنده , , Tadiparthi and Khan، نويسنده , , M. Naseer A. Khan، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
5
From page
55
To page
59
Abstract
Lipase-catalyzed resolution of 1-chloro-3-[(4-morpholin-4-yl-1,2,5-thiadiazole-3-yl)oxy]propan-2-ol (5) is described using vinyl acetate as acyl donor. The effect of different lipases from various sources in several solvents has been studied. This intermediate 5 is utilized in the preparation of enantiomerically enriched (R) and (S)-timolol.
Keywords
Lipases , Enantioselectivity , Timolol , Transesterification , ?-Adrenergic blockers
Journal title
Journal of Molecular Catalysis B Enzymatic
Serial Year
2008
Journal title
Journal of Molecular Catalysis B Enzymatic
Record number
1713380
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