Transformation of isoxanthohumol by fungi

Isoxanthohumol is the most abundant and an important prenylated flavonoid present in hopped beers. In order to select microorganisms capable of transforming isoxanthohumol screening tests on 44 fungi cultures were performed. This kind of activity has not been previously examined. Beauveria bassiana AM278 and Absidia glauca AM177 converted isoxanthohumol into glucoside derivatives, whereas Fusarium equiseti AM15 transformed it into (2R)-2″-(2″′-hydroxyisopropyl)-dihydrofurano[2″,3″:7,8]-4′-hydroxy-5-methoxyflavanone with high efficiency. Isoxanthohumol 7-O-β-d-4″′-methoxyglucopyranoside is a new compound.