A highly efficient chemoselective synthesis of 3,5-diketoesters by lipase-catalyzed transesterification: application to the resolution of secondary alcohols

A large number of 3,5-diketoesters have been synthesized by an immobilized lipase-catalyzed transesterification reaction. Excellent yields and chemoselectivity were observed. The immobilized lipase could be reused without significant loss of activity up to three reaction cycles. The same enzyme system has been used for resolution of secondary alcohols. Overall good chemical and optical yield were observed.