Title of article
Ficin-catalyzed asymmetric aldol reactions of heterocyclic ketones with aldehydes
Author/Authors
Fu، نويسنده , , Jianping and Gao، نويسنده , , Rui-Na and Yang، نويسنده , , Yang and Guan، نويسنده , , Zhi and He، نويسنده , , Yan-Hong، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2013
Pages
4
From page
1
To page
4
Abstract
Ficin from fig tree latex displayed a promiscuous activity to catalyze the direct asymmetric aldol reactions of heterocyclic ketones with aromatic aldehydes. Ficin showed good substrate adaptability to different heterocyclic ketones containing nitrogen, oxygen or sulfur. The enantioselectivities up to 81% ee and diastereoselectivities up to 86:14 (anti/syn) were achieved under the optimized reaction conditions.
Keywords
Enzymatic promiscuity , Ficin , Heterocyclic ketones , Asymmetric aldol reaction
Journal title
Journal of Molecular Catalysis B Enzymatic
Serial Year
2013
Journal title
Journal of Molecular Catalysis B Enzymatic
Record number
1718189
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