Title of article
Combined batch and continuous flow procedure to the chemo-enzymatic synthesis of biaryl moiety of Odanacatib
Author/Authors
de Oliveira Lopes، نويسنده , , Raquel Matos de Miranda Torrinhas، نويسنده , , Amanda S. and Reichart، نويسنده , , Benedikt and Glasnov، نويسنده , , Toma and Kappe، نويسنده , , C. Oliver and Simon، نويسنده , , Robert C. and Kroutil، نويسنده , , Wolfgang and Miranda، نويسنده , , Leandro S.M. and Leal، نويسنده , , Ivana C.R. and de Souza، نويسنده , , Rodrigo O.M.A.، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2014
Pages
7
From page
101
To page
107
Abstract
The development of chemo-enzymatic reaction under continuous flow conditions is an emerging area where biotechnology and organic chemistry can joint efforts in order to develop better process. Here in we report our effort on the development of a continuous flow approach to the synthesis of Odanacatib intermediate using a combined batch and continuous flow apparatus arriving on the desired molecule in excellent yields and selectivity.
Keywords
Odanacatib , Continuous process , Cascade reaction , Flow chemistry , Bioreduction
Journal title
Journal of Molecular Catalysis B Enzymatic
Serial Year
2014
Journal title
Journal of Molecular Catalysis B Enzymatic
Record number
1718809
Link To Document