Title of article
A unified model for studying DNA damage-induced p53–Mdm2 interaction
Author/Authors
Yan، نويسنده , , Shiwei and Zhuo، نويسنده , , Yizhong، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
6
From page
157
To page
162
Abstract
Exploring the nonlinear dynamics of the negative feedback loop composed of p53 and Mdm2 proteins, we propose a signal–response model to study the dynamical mechanism of the different oscillatory behaviors for the activities of p53 and Mdm2 proteins both in individual and populations of cells. It will be shown that the sustained and damped oscillatory dynamics could be described in a unified way when the dynamics of the damage-derived signal is properly introduced.
Keywords
p53–Mdm2 interaction , Negative feedback loop , Sustained and damped oscillatory dynamics
Journal title
Physica D Nonlinear Phenomena
Serial Year
2006
Journal title
Physica D Nonlinear Phenomena
Record number
1727900
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