Role of network connectivity in intercellular calcium signaling

It is important to understand the coordinated performance of cells in tissue. One possible mechanism in this coordination involves intracellular Ca2+ signaling. The topology of intercellular connections in tissue should also play an important role in this process. It is most relevant for plane tissues, in which the interaction between cells is due to gap junctions (epithelium, blood vessels). We demonstrate the importance of the topology of intercellular connectivity by investigating the properties of a model of Ca2+ signaling for a small number of connected cells.