Biological Activity and Efficient Synthesis of 3, 4-Dihydropyrimidin-2-(1H)-one/thione Derivatives

The present study aimed to use a method for the synthesis of some 3, 4-dihydropyrimidin-2-(1H) - ones/thiones. The study tried to answer the question whether this reaction can be performed without solvent and with new catalyst or not. To find answer to the question, we described a novel protocol for the efficient synthesis of 3, 4-dihydropyrimidin-2-(1H)-one derivatives using aromatic aldehyde, ethylacetoacetate, and urea/thiourea under solvent-free conditions by using SiO₂-CaCl₂as acatalyst. Using this catalyst has some advantages; itʹs high yields, usable in mild conditions, available, reusable, ecofriendly, cost effective and environmentally friendly. The structural features of the synthesized compounds were characterized by IR, ¹H NMR and ¹³C NMR. The compounds were screened for antimicrobial activity. The results showed these compounds react against all the tested bacteria. We have demonstrated a novel method for the synthesis of substituted dihydropyrimidinones catalyzed by SiO₂-CaCl₂ under solvent-free conditions.

The present study aimed to use a method for the synthesis of some 3, 4-dihydropyrimidin-2-(1H) - ones/thiones. The study tried to answer the question whether this reaction can be performed without solvent and with new catalyst or not. To find answer to the question, we described a novel protocol for the efficient synthesis of 3, 4-dihydropyrimidin-2-(1H)-one derivatives using aromatic aldehyde, ethylacetoacetate, and urea/thiourea under solvent-free conditions by using SiO₂-CaCl₂as acatalyst. Using this catalyst has some advantages; itʹs high yields, usable in mild conditions, available, reusable, ecofriendly, cost effective and environmentally friendly. The structural features of the synthesized compounds were characterized by IR, ¹H NMR and ¹³C NMR. The compounds were screened for antimicrobial activity. The results showed these compounds react against all the tested bacteria. We have demonstrated a novel method for the synthesis of substituted dihydropyrimidinones catalyzed by SiO₂-CaCl₂ under solvent-free conditions.