Title of article
Cobalt from metal-on-metal hip replacements may be the clinically relevant active agent responsible for periprosthetic tissue reactions
Author/Authors
Hart، نويسنده , , Alister J. and Quinn، نويسنده , , Paul D. and Lali، نويسنده , , Ferdinand and Sampson، نويسنده , , Barry and Skinner، نويسنده , , John A. and Powell، نويسنده , , Jonathan J. and Nolan، نويسنده , , John and Tucker، نويسنده , , Keith and Donell، نويسنده , , Simon and Flanagan، نويسنده , , Adrienne and Mosselmans، نويسنده , , J. Fred W. Mosselmans، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2012
Pages
9
From page
3865
To page
3873
Abstract
Some types of metal-on-metal (MOM) hip replacements have unacceptably high rates of failure, such as the Ultima TPS MOM hip, with 13.8% failure at 5 years. This has been attributed to an inflammatory reaction following the release of cobalt (Co) and chromium (Cr) from the bearing surfaces and modular junctions. There is in vitro evidence that Co is more important than Cr in the inflammatory process, but there are no reported human tissue studies of the analysis of implant-derived metals.
Keywords
Synchrotron , Metal-on-metal hip arthroplasty , CHEMICAL ANALYSIS , Periprosthetic tissue , Inflammatory response
Journal title
Acta Biomaterialia
Serial Year
2012
Journal title
Acta Biomaterialia
Record number
1756508
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