Title of article
Altered expression of NFY-C and RORA in colorectal adenocarcinomas
Author/Authors
Kottorou، نويسنده , , Anastasia E. and Antonacopoulou، نويسنده , , Anna G. and Dimitrakopoulos، نويسنده , , Fotinos-Ioannis D. and Tsamandas، نويسنده , , Athanasios C. and Scopa، نويسنده , , Chrisoula D. and Petsas، نويسنده , , Theodore and Kalofonos، نويسنده , , Haralabos P.، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2012
Pages
9
From page
553
To page
561
Abstract
NFY-C, a subunit of the transcription factor NFY, binds to the promoters of several eukaryotic genes, including cell cycle-related genes. RORA is a steroid hormone receptor implicated in a range of important cellular processes. We evaluated the expression of NFY-C and RORA in colorectal adenocarcinomas and normal colonic tissue. NFY-C expression was elevated in adenocarcinomas. Moreover, NFY-C mRNA levels correlated with time to disease progression, while NFY-C protein expression was significantly higher in metastatic disease. RORA expression was downregulated in CRC adenocarcinomas compared to normal controls and correlated with time to disease progression. The role of NFY-C and RORA in CRC merits further investigation.
Keywords
MRNA , Colorectal adenocarcinoma , immunohistochemistry , Clinicopathological characteristics , Disease progression , Primary site
Journal title
Acta Histochemica
Serial Year
2012
Journal title
Acta Histochemica
Record number
1760085
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