Alpha-lipoic acid as a new treatment option for Azheimer type dementia

Oxidative stress and energy depletion are characteristic biochemical hallmarks of Alzheimerʹs disease (AD), thus antioxidants with positive effects on glucose metabolism such as thioctic (α-lipoic) acid should exert positive effects in these patients. Therefore, 600 mg α-lipoic acid was given daily to nine patients with AD and related dementias (receiving a standard treatment with acetylcholinesterase inhibitors) in an open study over an observation period of, on avarage, 337±80 days. The treatment led to a stabilization of cognitive functions in the study group, demonstrated by constant scores in two neuropsychological tests (mini-mental state examination: MMSE and AD assessment scale, cognitive subscale: ADAScog). Despite the fact that this study was small and not randomized, this is the first indication that treatment with α-lipoic acid might be a successful ‘neuroprotective’ therapy option for AD and related dementias.