Molecular volume, surface area, and curvature dependence of the configurational entropy change upon solvation: effects of molecular bonding

The dependence of configurational entropy change in the fused hard-sphere reference system upon solvation on the soluteʹs volume, surface, and curvature is investigated by using the thermodynamical perturbation theory of the fused hard spheres based on a rigorous treatment of the PV term. It is shown that no volume-proportional terms exist in the solvation free energy for spherical solutes, except for the PV term which is usually negligible in liquids. The effect of soluteʹs and solventʹs chain length on the configurational entropy is also presented.