Title of article
Positive correlation of plasma transforming growth factor-β1 levels with tumor vascularity in hepatocellular carcinoma
Author/Authors
Ito، نويسنده , , Nobuyuki and Kawata، نويسنده , , Sumio and Tamura، نويسنده , , Shinji and Shirai، نويسنده , , Yasuhiro and Kiso، نويسنده , , Shinichi and Tsushima، نويسنده , , Hirofumi and Matsuzawa، نويسنده , , Yuji، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1995
Pages
4
From page
45
To page
48
Abstract
Transforming growth factor-β1 (TGF-β1) has been implicated in tumor progression by promoting angiogenesis or suppressing immune system. We reported previously that transforming growth factor-β1 (TGF-β1) is overproduced by human hepatocellular carcinoma (HCC) tissues and that plasma TGF-β1 levels are elevated in patients with HCC. In the present study, we investigated the relationship between plasma TGF-β1 levels and tumor vascularity as assessed by conventional celiac angiography in 17 patients with HCC. The plasma TGF-β1 level did not correlate with tumor size or underlying liver disease. However, we found that plasma TGF-β1 levels correlated positively with the tumor vascularity. These results suggest that excessive TGF-β1 production may contribute to tumor angiogenesis in HCC.
Keywords
Tumor vascularity , Transforming growth factor-?1 , hepatocellular carcinoma , Angiogenesis
Journal title
Cancer Letters
Serial Year
1995
Journal title
Cancer Letters
Record number
1796398
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