Title of article
Inhibition by verapamil of cholecystokinin-enhancement of pancreatic carcinogenesis induced by azaserine in Wistar rats
Author/Authors
Hiroyuki and Nakaizumi، نويسنده , , Akihiko and Uehara، نويسنده , , Hiroyuki and Baba، نويسنده , , Miyako and Iishi، نويسنده , , Hiroyasu and Tatsuta، نويسنده , , Masaharu، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1996
Pages
5
From page
23
To page
27
Abstract
The effect of a calcium channel blocker, verapamil, on cholecystokinin (CCK)-enhancement of pancreatic carcinogenesis induced by azaserine was investigated in Wistar rats. During and after 25 weekly injections of azaserine, each rat received alternate-day injections of CCK-octapeptide (CCK-8) and/or verapamil. Carcinogen-induced pancreatic lesions staining for μ class glutathione 5-transferase (GST-μ) were examined histochemically at week 62. Prolonged administration of CCK-8 significantly increased the number and area as a percentage of parenchyma of GST-μ-positive lesions. Concomitant administration of verapamil significantly attenuated the enhancing effect of CCK-8. These findings indicate that calcium may play an important role in CCK-enhancement of pancreatic carcinogenesis.
Keywords
Verapamil , Pancreatic carcinogenesis , ? Class glutathione S-transferase , Azaserine , Cholecystokinin , Inhibition
Journal title
Cancer Letters
Serial Year
1996
Journal title
Cancer Letters
Record number
1797330
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