Title of article
Simultaneous expression of cadherin-11 in signet-ring cell carcinoma and stromal cells of diffuse-type gastric cancer
Author/Authors
Shibata، نويسنده , , Tatsuhiro and Ochiai، نويسنده , , Atsushi and Gotoh، نويسنده , , Masahiro and Machinami، نويسنده , , Rikuo and Hirohashi، نويسنده , , Setsuo، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1996
Pages
7
From page
147
To page
153
Abstract
We examined the expression of cadherin-11, a type II cadherin, in normal human tissues, cell lines and gastric cancer surgical specimens. Cadherin-11 was expressed widely in adult tissues, except the liver. It was expressed in fibroblast, mesothelial cell lines, and in only two signet ring cell carcinomas out of 16 various cancer cell lines. Cadherin-11 expression was detected in both signet ring cell carcinoma cells and surrounding fibroblasts of surgical specimens by in situ hybridization. These results suggest that cadherin-11 may play a role in the formation of diffuse-type gastric cancer through cancer-stromal interactions.
Keywords
Type II cadherin , fibroblast , Cancer-stromal interaction , Signet ring cell carcinoma , Diffuse-type gastric cancer
Journal title
Cancer Letters
Serial Year
1996
Journal title
Cancer Letters
Record number
1797685
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