Title of article
Migration and gap junctional intercellular communication determine the metastatic phenotype of human tumor cell lines
Author/Authors
Navolotski، نويسنده , , Alexander and Rumjnzev، نويسنده , , Alexander and Lü، نويسنده , , Hongqi and Proft، نويسنده , , Dirk and Bartholmes، نويسنده , , Peter and Zنnker، نويسنده , , Kurt S.، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1997
Pages
7
From page
181
To page
187
Abstract
Gap junctional intercellular communication (GJIC) as well as cell migration play an essential role in the metastatic cascade of human tumors. We show a dependence of metastatogenic phenotypes of human tumor cells (cell lines T 24, SCC-25, MDA-MB-361 and SK-BR-3) from the GJIC and the migration activity. The GJIC was studied by microinjection of the fluorescent dye Lucifer Yellow (LY) and cell migration was studied by investigating the locomotion of the tumor cells in 3-dimensional collagen matrices. Diminished GJIC seems to be more influential for the metastatic phenotype than modulation of the locomotory behavior of the tumor cells.
Keywords
Collagen synthesis , Cell migration , Intercellular communication , Metastatogenic phenotype , Human tumor cell lines
Journal title
Cancer Letters
Serial Year
1997
Journal title
Cancer Letters
Record number
1798750
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