Title of article
Quercetin enhances pretumorous lesions in the NMU model of rat pancreatic carcinogenesis
Author/Authors
Barotto، نويسنده , , Nelso N and L?pez، نويسنده , , Cristina B and Eynard، نويسنده , , Aldo R and Fern?ndez Zapico، نويسنده , , Mart??n E and Valentich، نويسنده , , Mirta A، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1998
Pages
6
From page
1
To page
6
Abstract
The effect of dietary quercetin (Q) was evaluated in rats treated with nitrosomethylurea (NMU). Pancreatic nodules and focal acinar cell hyperplasias were observed in groups treated with NMU (87%) and Q-NMU (100%). Although rats with dysplastic foci (27%) were found in the NMU-treated group, Q-NMU treatment resulted in a significantly higher number of rats with dysplastic foci (73%). Furthermore, carcinomas in situ (12%) and one microcarcinoma (4%) were found in these animals. Mitosis was significantly increased and apoptosis was diminished in focal acinar cell hyperplasias of the Q-NMU group. Our present results support a promoting and progressing effect of quercetin in the NMU model of rat pancreatic carcinogenesis.
Keywords
Quercetin , Nitrosomethylurea , progression , Pancreatic carcinogenesis , PROMOTION
Journal title
Cancer Letters
Serial Year
1998
Journal title
Cancer Letters
Record number
1799567
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