Dimethylarsinic acid effects on DNA damage and oxidative stress related biochemical parameters in B6C3F1 mice

Adult female B6C3F1 mice were given 720 mg/kg of DMA by oral gavage at one of three times (2 h, 15 h, or at both 21 and 4 h) before sacrifice. Significant (P<0.05) decreases in liver GSH and GSSG contents (15–37%) were observed. Some evidence of DMA-induced hepatic DNA damage (at the P<0.10 level only) was observed. Pulmonary and hepatic ODC activities were reduced (19–59%) by DMA treatment. Overall, these biochemical studies show that mice are much less responsive to DMA than rats.